[Development of the cDNA chip for SARS virus and a primary study on the possible molecular mechanism of interferon alpha2b inhibiting the SARS virus replication].
Identifieur interne : 005C65 ( Main/Exploration ); précédent : 005C64; suivant : 005C66[Development of the cDNA chip for SARS virus and a primary study on the possible molecular mechanism of interferon alpha2b inhibiting the SARS virus replication].
Auteurs : Yue-Long Shu [République populaire de Chine] ; Zhao-Jun Duan ; Zheng Wang ; Mei-Sheng Sun ; Jing Zhang ; Li-Lan Zhang ; Xue-Jun Ma ; Jun-Ping Peng ; Qi Jin ; Yun-De HouSource :
- Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology [ 1003-9279 ] ; 2003.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Humains, Interféron alpha (pharmacologie), Protéines recombinantes, Réplication virale (), Syndrome respiratoire aigu sévère (virologie), Séquençage par oligonucléotides en batterie (), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Virus du SRAS (physiologie).
- MESH :
- génétique : ARN viral, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- pharmacologie : Interféron alpha.
- physiologie : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Humains, Protéines recombinantes, Réplication virale, Séquençage par oligonucléotides en batterie, Virus du SRAS.
English descriptors
- KwdEn :
- Humans, Interferon alpha-2, Interferon-alpha (pharmacology), Oligonucleotide Array Sequence Analysis (methods), RNA, Viral (genetics), Recombinant Proteins, SARS Virus (drug effects), SARS Virus (genetics), SARS Virus (isolation & purification), SARS Virus (physiology), Severe Acute Respiratory Syndrome (virology), Virus Replication (drug effects).
- MESH :
- chemical , genetics : RNA, Viral.
- chemical , pharmacology : Interferon-alpha.
- chemical : Interferon alpha-2, Recombinant Proteins.
- drug effects : SARS Virus, Virus Replication.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- methods : Oligonucleotide Array Sequence Analysis.
- physiology : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Humans.
Abstract
To study the molecular mechanism of interferon alpha2b(IFNalpha2b) inhibiting the SARS virus replication. SARS-associated coronavirus (SARS virus) cDNA chip was developed and applied to detect the virus RNA transcription levels in the interferon-treated and untreated cell cultures, and the mechanism of anti-SARS virus activity of interferon alpha2b in cell culture system was explored.
PubMed: 15340559
Affiliations:
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Le document en format XML
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first="Yun-De" last="Hou">Yun-De Hou</name></author></analytic><series><title level="j">Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology</title><idno type="ISSN">1003-9279</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Interferon alpha-2</term><term>Interferon-alpha (pharmacology)</term><term>Oligonucleotide Array Sequence Analysis (methods)</term><term>RNA, Viral (genetics)</term><term>Recombinant Proteins</term><term>SARS Virus (drug effects)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN 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SARS-associated coronavirus (SARS virus) cDNA chip was developed and applied to detect the virus RNA transcription levels in the interferon-treated and untreated cell cultures, and the mechanism of anti-SARS virus activity of interferon alpha2b in cell culture system was explored.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Duan, Zhao Jun" sort="Duan, Zhao Jun" uniqKey="Duan Z" first="Zhao-Jun" last="Duan">Zhao-Jun Duan</name><name sortKey="Hou, Yun De" sort="Hou, Yun De" uniqKey="Hou Y" first="Yun-De" last="Hou">Yun-De Hou</name><name sortKey="Jin, Qi" sort="Jin, Qi" uniqKey="Jin Q" first="Qi" last="Jin">Qi Jin</name><name sortKey="Ma, Xue Jun" sort="Ma, Xue Jun" uniqKey="Ma X" first="Xue-Jun" last="Ma">Xue-Jun Ma</name><name sortKey="Peng, Jun Ping" sort="Peng, Jun Ping" uniqKey="Peng J" first="Jun-Ping" last="Peng">Jun-Ping Peng</name><name sortKey="Sun, Mei Sheng" sort="Sun, Mei Sheng" uniqKey="Sun M" first="Mei-Sheng" last="Sun">Mei-Sheng Sun</name><name sortKey="Wang, Zheng" sort="Wang, Zheng" uniqKey="Wang Z" first="Zheng" last="Wang">Zheng Wang</name><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><name sortKey="Zhang, Li Lan" sort="Zhang, Li Lan" uniqKey="Zhang L" first="Li-Lan" last="Zhang">Li-Lan Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Shu, Yue Long" sort="Shu, Yue Long" uniqKey="Shu Y" first="Yue-Long" last="Shu">Yue-Long Shu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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